Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation.
Identifieur interne : 001378 ( Main/Exploration ); précédent : 001377; suivant : 001379Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation.
Auteurs : Antoine Beurnier [France] ; Etienne-Marie Jutant [France] ; Mitja Jevnikar [France] ; Athénaïs Boucly [France] ; Jérémie Pichon [France] ; Mariana Preda [France] ; Marie Frank [France] ; Jérémy Laurent [France] ; Christian Richard [France] ; Xavier Monnet [France] ; Jacques Duranteau [France] ; Anatole Harrois [France] ; Marie-Camille Chaumais [France] ; Marie-France Bellin [France] ; Nicolas Noël [France] ; Sophie Bulifon [France] ; Xavier Jaïs [France] ; Florence Parent [France] ; Andrei Seferian [France] ; Laurent Savale [France] ; Olivier Sitbon [France] ; David Montani [France] ; Marc Humbert [France]Source :
- The European respiratory journal [ 1399-3003 ] ; 2020.
Abstract
BACKGROUND
Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility of asthmatics to develop an exacerbation when they present with severe pneumonia due to SARS-CoV-2 infection is unknown. The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France.
METHODS
A prospective cohort follow-up was carried out from March 15 to April 15, 2020 in Bicêtre Hospital, University Paris-Saclay, France. All hospitalised patients with a SARS-CoV-2 infection who reported a history of asthma were included.
RESULTS
Among 768 hospitalised patients, 37 (4.8%) reported a history of asthma, which had been previously confirmed by a pulmonologist in 85% of cases. Patients were mainly female (70%), non-smokers (85%), with a median age of 54 years (interquartile range, IQR 42-67). None of them presented with an asthma exacerbation. Twenty-two (59%) had major comorbidities and 31 (84%) had a body mass index ≥25 kg·m
CONCLUSION
Asthmatics were not overrepresented among patients with severe pneumonia due to SARS-CoV-2 infection who required hospitalisation. Worst outcomes were observed mainly in patients with major comorbidities.
DOI: 10.1183/13993003.01875-2020
PubMed: 32732333
PubMed Central: PMC7397950
Affiliations:
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France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le 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Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Chaumais, Marie Camille" sort="Chaumais, Marie Camille" uniqKey="Chaumais M" first="Marie-Camille" last="Chaumais">Marie-Camille Chaumais</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pharmacie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pharmacie, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Bellin, Marie France" sort="Bellin, Marie France" uniqKey="Bellin M" first="Marie-France" last="Bellin">Marie-France Bellin</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service d'imagerie médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service d'imagerie médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Noel, Nicolas" sort="Noel, Nicolas" uniqKey="Noel N" first="Nicolas" last="Noël">Nicolas Noël</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de médecine interne, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de médecine interne, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Bulifon, Sophie" sort="Bulifon, Sophie" uniqKey="Bulifon S" first="Sophie" last="Bulifon">Sophie Bulifon</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Jais, Xavier" sort="Jais, Xavier" uniqKey="Jais X" first="Xavier" last="Jaïs">Xavier Jaïs</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Parent, Florence" sort="Parent, Florence" uniqKey="Parent F" first="Florence" last="Parent">Florence Parent</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Seferian, Andrei" sort="Seferian, Andrei" uniqKey="Seferian A" first="Andrei" last="Seferian">Andrei Seferian</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Montani, David" sort="Montani, David" uniqKey="Montani D" first="David" last="Montani">David Montani</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32732333</idno><idno type="pmid">32732333</idno><idno type="doi">10.1183/13993003.01875-2020</idno><idno type="pmc">PMC7397950</idno><idno type="wicri:Area/Main/Corpus">000777</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000777</idno><idno type="wicri:Area/Main/Curation">000777</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000777</idno><idno type="wicri:Area/Main/Exploration">000777</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation.</title><author><name sortKey="Beurnier, Antoine" sort="Beurnier, Antoine" uniqKey="Beurnier A" first="Antoine" last="Beurnier">Antoine Beurnier</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de physiologie et d'explorations fonctionnelles respiratoires (CRISALIS/F-CRIN network), Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de physiologie et d'explorations fonctionnelles respiratoires (CRISALIS/F-CRIN network), Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Jutant, Etienne Marie" sort="Jutant, Etienne Marie" uniqKey="Jutant E" first="Etienne-Marie" last="Jutant">Etienne-Marie Jutant</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Jevnikar, Mitja" sort="Jevnikar, Mitja" uniqKey="Jevnikar M" first="Mitja" last="Jevnikar">Mitja Jevnikar</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Boucly, Athenais" sort="Boucly, Athenais" uniqKey="Boucly A" first="Athénaïs" last="Boucly">Athénaïs Boucly</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Pichon, Jeremie" sort="Pichon, Jeremie" uniqKey="Pichon J" first="Jérémie" last="Pichon">Jérémie Pichon</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Preda, Mariana" sort="Preda, Mariana" uniqKey="Preda M" first="Mariana" last="Preda">Mariana Preda</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Frank, Marie" sort="Frank, Marie" uniqKey="Frank M" first="Marie" last="Frank">Marie Frank</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Département d'information médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Département d'information médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Laurent, Jeremy" sort="Laurent, Jeremy" uniqKey="Laurent J" first="Jérémy" last="Laurent">Jérémy Laurent</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Département d'information médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Département d'information médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Richard, Christian" sort="Richard, Christian" uniqKey="Richard C" first="Christian" last="Richard">Christian Richard</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de médecine intensive-réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de médecine intensive-réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Monnet, Xavier" sort="Monnet, Xavier" uniqKey="Monnet X" first="Xavier" last="Monnet">Xavier Monnet</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de médecine intensive-réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de médecine intensive-réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Harrois, Anatole" sort="Harrois, Anatole" uniqKey="Harrois A" first="Anatole" last="Harrois">Anatole Harrois</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Chaumais, Marie Camille" sort="Chaumais, Marie Camille" uniqKey="Chaumais M" first="Marie-Camille" last="Chaumais">Marie-Camille Chaumais</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pharmacie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pharmacie, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Bellin, Marie France" sort="Bellin, Marie France" uniqKey="Bellin M" first="Marie-France" last="Bellin">Marie-France Bellin</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service d'imagerie médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service d'imagerie médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Noel, Nicolas" sort="Noel, Nicolas" uniqKey="Noel N" first="Nicolas" last="Noël">Nicolas Noël</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de médecine interne, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de médecine interne, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Bulifon, Sophie" sort="Bulifon, Sophie" uniqKey="Bulifon S" first="Sophie" last="Bulifon">Sophie Bulifon</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Jais, Xavier" sort="Jais, Xavier" uniqKey="Jais X" first="Xavier" last="Jaïs">Xavier Jaïs</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Parent, Florence" sort="Parent, Florence" uniqKey="Parent F" first="Florence" last="Parent">Florence Parent</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Seferian, Andrei" sort="Seferian, Andrei" uniqKey="Seferian A" first="Andrei" last="Seferian">Andrei Seferian</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Montani, David" sort="Montani, David" uniqKey="Montani D" first="David" last="Montani">David Montani</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><affiliation wicri:level="1"><nlm:affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S 999, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author></analytic><series><title level="j">The European respiratory journal</title><idno type="eISSN">1399-3003</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility of asthmatics to develop an exacerbation when they present with severe pneumonia due to SARS-CoV-2 infection is unknown. The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A prospective cohort follow-up was carried out from March 15 to April 15, 2020 in Bicêtre Hospital, University Paris-Saclay, France. All hospitalised patients with a SARS-CoV-2 infection who reported a history of asthma were included.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Among 768 hospitalised patients, 37 (4.8%) reported a history of asthma, which had been previously confirmed by a pulmonologist in 85% of cases. Patients were mainly female (70%), non-smokers (85%), with a median age of 54 years (interquartile range, IQR 42-67). None of them presented with an asthma exacerbation. Twenty-two (59%) had major comorbidities and 31 (84%) had a body mass index ≥25 kg·m</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Asthmatics were not overrepresented among patients with severe pneumonia due to SARS-CoV-2 infection who required hospitalisation. Worst outcomes were observed mainly in patients with major comorbidities.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32732333</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1399-3003</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>30</Day></PubDate></JournalIssue><Title>The European respiratory journal</Title><ISOAbbreviation>Eur. Respir. J.</ISOAbbreviation></Journal><ArticleTitle>Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">2001875</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1183/13993003.01875-2020</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Viral respiratory infections are the main causes of asthma exacerbation. The susceptibility of asthmatics to develop an exacerbation when they present with severe pneumonia due to SARS-CoV-2 infection is unknown. The objective of this study was to investigate the characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who required hospitalisation during the spring 2020 outbreak in Paris, France.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A prospective cohort follow-up was carried out from March 15 to April 15, 2020 in Bicêtre Hospital, University Paris-Saclay, France. All hospitalised patients with a SARS-CoV-2 infection who reported a history of asthma were included.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 768 hospitalised patients, 37 (4.8%) reported a history of asthma, which had been previously confirmed by a pulmonologist in 85% of cases. Patients were mainly female (70%), non-smokers (85%), with a median age of 54 years (interquartile range, IQR 42-67). None of them presented with an asthma exacerbation. Twenty-two (59%) had major comorbidities and 31 (84%) had a body mass index ≥25 kg·m<sup>-2</sup>. The most common comorbidities were obesity (36%), hypertension (27%) and diabetes (19%). All patients had a confirmed diagnosis of COVID-19 pneumonia on computed tomography of the chest. Eosinopenia was a typical biologic feature with a median count of 0/mm3 (IQR 0-0). Eleven patients (30%) were admitted in intensive care unit with three death (8.1%) occurring in the context of comorbidities.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Asthmatics were not overrepresented among patients with severe pneumonia due to SARS-CoV-2 infection who required hospitalisation. Worst outcomes were observed mainly in patients with major comorbidities.</AbstractText><CopyrightInformation>Copyright ©ERS 2020.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Beurnier</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de physiologie et d'explorations fonctionnelles respiratoires (CRISALIS/F-CRIN network), Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jutant</LastName><ForeName>Etienne-Marie</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jevnikar</LastName><ForeName>Mitja</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boucly</LastName><ForeName>Athénaïs</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pichon</LastName><ForeName>Jérémie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preda</LastName><ForeName>Mariana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frank</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AP-HP, Département d'information médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laurent</LastName><ForeName>Jérémy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>AP-HP, Département d'information médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richard</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de médecine intensive-réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monnet</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de médecine intensive-réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duranteau</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrois</LastName><ForeName>Anatole</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Département d'anesthésie et réanimation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaumais</LastName><ForeName>Marie-Camille</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pharmacie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellin</LastName><ForeName>Marie-France</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service d'imagerie médicale, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noël</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de médecine interne, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bulifon</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jaïs</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parent</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seferian</LastName><ForeName>Andrei</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savale</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-6862-8975</Identifier><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sitbon</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-1942-1951</Identifier><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montani</LastName><ForeName>David</ForeName><Initials>D</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9358-6922</Identifier><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Humbert</LastName><ForeName>Marc</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-0703-2892</Identifier><AffiliationInfo><Affiliation>Université Paris-Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM UMR_S 999, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>AP-HP, Service de pneumologie et soins intensifs respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur Respir J</MedlineTA><NlmUniqueID>8803460</NlmUniqueID><ISSNLinking>0903-1936</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CoiStatement>Conflict of interest: Dr. Beurnier has nothing to disclose. Conflict of interest: Dr. Jutant has nothing to disclose. Conflict of interest: Dr. Jevnikar has nothing to disclose. Conflict of interest: Dr. Boucly has nothing to disclose. Conflict of interest: Dr. Pichon has nothing to disclose. Conflict of interest: Dr. Preda has nothing to disclose. Conflict of interest: Dr. Frank has nothing to disclose. Conflict of interest: Dr. Laurent has nothing to disclose. Conflict of interest: Dr. Richard has nothing to disclose. Conflict of interest: Dr. Monnet has nothing to disclose. Conflict of interest: Dr. Duranteau has nothing to disclose. Conflict of interest: Dr. Harrois has nothing to disclose. Conflict of interest: Dr. Chaumais has nothing to disclose. Conflict of interest: Dr. Bellin has nothing to disclose. Conflict of interest: Dr. Noël has nothing to disclose. Conflict of interest: Dr. Bulifon has nothing to disclose. Conflict of interest: Dr. Jaïs has nothing to disclose. Conflict of interest: Dr. Parent has nothing to disclose. Conflict of interest: Dr. Seferian has nothing to disclose. Conflict of interest: Dr. Savale has nothing to disclose. Conflict of interest: Dr. Sitbon reports grants, personal fees and non-financial support from Actelion Pharmaceuticals, personal fees from Acceleron Pharmaceuticals, grants and personal fees from Bayer, grants, personal fees and non-financial support from MSD, personal fees from Gossamer Bio, personal fees from Ferrer, grants from GlaxoSmithKline, outside the submitted work. Dr. Humbert reports personal fees from Novartis, during the conduct of the study; grants, personal fees and non-financial support from GlaxoSmithKline, personal fees from Astrazeneca, personal fees from Novartis, personal fees from Roche, personal fees from Sanofi, personal fees from Teva, outside the submitted work. Conflict of interest: Dr. Montani has nothing to disclose. Conflict of interest: Dr. Humbert reports grants, personal fees and non-financial support from GlaxoSmithKline, personal fees from Astrazeneca, personal fees from Novartis, personal fees from Roche, personal fees from Sanofi, personal fees from Teva, outside the submitted work.Dr. Humbert reports personal fees from Novartis, during the conduct of the study; grants, personal fees and non-financial support from GlaxoSmithKline, personal fees from Astrazeneca, personal fees from Novartis, personal fees from Roche, personal fees from Sanofi, personal fees from Teva, outside the submitted work.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32732333</ArticleId><ArticleId IdType="pii">13993003.01875-2020</ArticleId><ArticleId IdType="doi">10.1183/13993003.01875-2020</ArticleId><ArticleId IdType="pmc">PMC7397950</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>CMAJ. 2008 Nov 18;179(11):1121-31</Citation><ArticleIdList><ArticleId IdType="pubmed">19015563</ArticleId></ArticleIdList></Reference><Reference><Citation>Circulation. 2020 Jul 7;142(1):4-6</Citation><ArticleIdList><ArticleId IdType="pubmed">32320270</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Chest Med. 2019 Mar;40(1):149-161</Citation><ArticleIdList><ArticleId 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IdType="pubmed">32333915</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Beurnier, Antoine" sort="Beurnier, Antoine" uniqKey="Beurnier A" first="Antoine" last="Beurnier">Antoine Beurnier</name></noRegion><name sortKey="Bellin, Marie France" sort="Bellin, Marie France" uniqKey="Bellin M" first="Marie-France" last="Bellin">Marie-France Bellin</name><name sortKey="Bellin, Marie France" sort="Bellin, Marie France" uniqKey="Bellin M" first="Marie-France" last="Bellin">Marie-France Bellin</name><name sortKey="Beurnier, Antoine" sort="Beurnier, Antoine" uniqKey="Beurnier A" first="Antoine" last="Beurnier">Antoine Beurnier</name><name sortKey="Beurnier, Antoine" sort="Beurnier, Antoine" uniqKey="Beurnier A" first="Antoine" last="Beurnier">Antoine Beurnier</name><name sortKey="Boucly, Athenais" sort="Boucly, Athenais" uniqKey="Boucly A" first="Athénaïs" last="Boucly">Athénaïs Boucly</name><name sortKey="Boucly, Athenais" sort="Boucly, Athenais" uniqKey="Boucly A" first="Athénaïs" last="Boucly">Athénaïs Boucly</name><name sortKey="Boucly, Athenais" sort="Boucly, Athenais" uniqKey="Boucly A" first="Athénaïs" last="Boucly">Athénaïs Boucly</name><name sortKey="Bulifon, Sophie" sort="Bulifon, Sophie" uniqKey="Bulifon S" first="Sophie" last="Bulifon">Sophie Bulifon</name><name sortKey="Bulifon, Sophie" sort="Bulifon, Sophie" uniqKey="Bulifon S" first="Sophie" last="Bulifon">Sophie Bulifon</name><name sortKey="Bulifon, Sophie" sort="Bulifon, Sophie" uniqKey="Bulifon S" first="Sophie" last="Bulifon">Sophie Bulifon</name><name sortKey="Chaumais, Marie Camille" sort="Chaumais, Marie Camille" uniqKey="Chaumais M" first="Marie-Camille" last="Chaumais">Marie-Camille Chaumais</name><name sortKey="Chaumais, Marie Camille" sort="Chaumais, Marie Camille" uniqKey="Chaumais M" first="Marie-Camille" last="Chaumais">Marie-Camille Chaumais</name><name 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first="Marc" last="Humbert">Marc Humbert</name><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><name sortKey="Jais, Xavier" sort="Jais, Xavier" uniqKey="Jais X" first="Xavier" last="Jaïs">Xavier Jaïs</name><name sortKey="Jais, Xavier" sort="Jais, Xavier" uniqKey="Jais X" first="Xavier" last="Jaïs">Xavier Jaïs</name><name sortKey="Jais, Xavier" sort="Jais, Xavier" uniqKey="Jais X" first="Xavier" last="Jaïs">Xavier Jaïs</name><name sortKey="Jevnikar, Mitja" sort="Jevnikar, Mitja" uniqKey="Jevnikar M" first="Mitja" last="Jevnikar">Mitja Jevnikar</name><name sortKey="Jevnikar, Mitja" sort="Jevnikar, Mitja" uniqKey="Jevnikar M" first="Mitja" last="Jevnikar">Mitja Jevnikar</name><name sortKey="Jevnikar, Mitja" sort="Jevnikar, Mitja" uniqKey="Jevnikar M" first="Mitja" last="Jevnikar">Mitja Jevnikar</name><name sortKey="Jutant, Etienne Marie" sort="Jutant, Etienne Marie" uniqKey="Jutant E" first="Etienne-Marie" last="Jutant">Etienne-Marie Jutant</name><name sortKey="Jutant, Etienne Marie" sort="Jutant, Etienne Marie" uniqKey="Jutant E" first="Etienne-Marie" last="Jutant">Etienne-Marie Jutant</name><name sortKey="Jutant, Etienne Marie" sort="Jutant, Etienne Marie" uniqKey="Jutant E" first="Etienne-Marie" last="Jutant">Etienne-Marie Jutant</name><name sortKey="Laurent, Jeremy" sort="Laurent, Jeremy" uniqKey="Laurent J" first="Jérémy" last="Laurent">Jérémy Laurent</name><name sortKey="Monnet, Xavier" sort="Monnet, Xavier" uniqKey="Monnet X" first="Xavier" last="Monnet">Xavier Monnet</name><name sortKey="Monnet, Xavier" sort="Monnet, Xavier" uniqKey="Monnet X" first="Xavier" last="Monnet">Xavier Monnet</name><name sortKey="Montani, David" sort="Montani, David" uniqKey="Montani D" first="David" last="Montani">David Montani</name><name sortKey="Montani, David" sort="Montani, David" uniqKey="Montani D" first="David" last="Montani">David Montani</name><name sortKey="Montani, David" sort="Montani, David" uniqKey="Montani D" first="David" last="Montani">David Montani</name><name sortKey="Noel, Nicolas" sort="Noel, Nicolas" uniqKey="Noel N" first="Nicolas" last="Noël">Nicolas Noël</name><name sortKey="Noel, Nicolas" sort="Noel, Nicolas" uniqKey="Noel N" first="Nicolas" last="Noël">Nicolas Noël</name><name sortKey="Parent, Florence" sort="Parent, Florence" uniqKey="Parent F" first="Florence" last="Parent">Florence Parent</name><name sortKey="Parent, Florence" sort="Parent, Florence" uniqKey="Parent F" first="Florence" last="Parent">Florence Parent</name><name sortKey="Parent, Florence" sort="Parent, Florence" uniqKey="Parent F" first="Florence" last="Parent">Florence Parent</name><name sortKey="Pichon, Jeremie" sort="Pichon, Jeremie" uniqKey="Pichon J" first="Jérémie" last="Pichon">Jérémie Pichon</name><name sortKey="Pichon, Jeremie" sort="Pichon, Jeremie" uniqKey="Pichon J" first="Jérémie" last="Pichon">Jérémie Pichon</name><name sortKey="Pichon, Jeremie" sort="Pichon, Jeremie" uniqKey="Pichon J" first="Jérémie" last="Pichon">Jérémie Pichon</name><name sortKey="Preda, Mariana" sort="Preda, Mariana" uniqKey="Preda M" first="Mariana" last="Preda">Mariana Preda</name><name sortKey="Preda, Mariana" sort="Preda, Mariana" uniqKey="Preda M" first="Mariana" last="Preda">Mariana Preda</name><name sortKey="Preda, Mariana" sort="Preda, Mariana" uniqKey="Preda M" first="Mariana" last="Preda">Mariana Preda</name><name sortKey="Richard, Christian" sort="Richard, Christian" uniqKey="Richard C" first="Christian" last="Richard">Christian Richard</name><name sortKey="Richard, Christian" sort="Richard, Christian" uniqKey="Richard C" first="Christian" last="Richard">Christian Richard</name><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name><name sortKey="Seferian, Andrei" sort="Seferian, Andrei" uniqKey="Seferian A" first="Andrei" last="Seferian">Andrei Seferian</name><name sortKey="Seferian, Andrei" sort="Seferian, Andrei" uniqKey="Seferian A" first="Andrei" last="Seferian">Andrei Seferian</name><name sortKey="Seferian, Andrei" sort="Seferian, Andrei" uniqKey="Seferian A" first="Andrei" last="Seferian">Andrei Seferian</name><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name><name sortKey="Sitbon, Olivier" sort="Sitbon, Olivier" uniqKey="Sitbon O" first="Olivier" last="Sitbon">Olivier Sitbon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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